Mesoestetic vs Sesderma — side by side, no bias.
Our pick
Cosmelan 2 Maintenance Cream
9/10 · Mesoestetic
| Cosmelan 2 Maintenance Cream | Azelac Gel Cream | |
|---|---|---|
| Brand | Mesoestetic | Sesderma |
| Category | moisturizer | moisturizer |
| Editor Rating | 9/10 ★ | 8/10 |
| Category | moisturizer | moisturizer |
| Texture | Rich treatment cream | Gel-cream |
| Finish | Smoothed, brightened, restored | Calmed, clarified |
| Skin Types |
| Targets |
| Pros |
|
|
| Cons |
|
|
| Verdict | Mesoestetic's at-home counterpart to the Cosmelan in-clinic depigmenting peel — and the most-prescribed melasma maintenance cream in global dermatology. The Cosmelan method is a two-step protocol: an in-clinic mask applied by an aesthetic physician, then 6-9 months of at-home Cosmelan 2 cream to maintain and extend the depigmenting effect. The maintenance cream's active stack is dense — azelaic acid, kojic acid, phytic acid, ascorbyl glucoside, retinyl palmitate, niacinamide, and arbutin all work in parallel through different melanin-synthesis pathways. The result is a cumulative, multi-month depigmenting protocol that can rival in-clinic results when used as directed. At $130 for 30g, premium pricing — but Cosmelan 2 alone (without the in-clinic peel) still delivers meaningful results for stubborn melasma that other OTC products can't move. | Sesderma's azelaic acid gel-cream — 10% azelaic in a moisturizer base. The Spanish-pharmacy answer to The Ordinary Azelaic 10% Suspension at premium positioning. Azelaic is the rosacea-and-melasma multi-tasker, and Sesderma's gel-cream format is daily-tolerant. |
