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Endocare's retinol serum — a dual-retinoid formulation that pairs classic retinol with hydroxypinacolone retinoate (HPR, a next-generation retinoid that binds directly to retinoid receptors without the conversion steps that cause irritation). The dual approach means the formulation delivers both immediate receptor activation (via HPR) and sustained retinoid activity (via retinol's slower conversion pathway). Layered with Argireline peptide for expression-line softening, hyaluronic acid for hydration, niacinamide for barrier support, and panthenol + allantoin for anti-irritation. At ~$45 for 30ml, mid-tier pricing — and the dual-retinoid approach is more sophisticated than most single-retinol serums at twice the price. The night serum Endocare's dermatology network prescribes for retinoid-tolerant patients who want clinical-grade results without the irritation of prescription tretinoin.
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Renewal Retinol Intensive Serum by Endocare is formulated for normal, combination, mature skin. Endocare's retinol serum — a dual-retinoid formulation that pairs classic retinol with hydroxypinacolone retinoate (HPR, a next-generation retinoid that binds directly to retinoid receptors without the conversion steps that cause irritation). The dual approach means the formulation delivers both immediate receptor activation (via HPR) and sustained retinoid activity (via retinol's slower conversion pathway). Layered with Argireline peptide for expression-line softening, hyaluronic acid for hydration, niacinamide for barrier support, and panthenol + allantoin for anti-irritation. At ~$45 for 30ml, mid-tier pricing — and the dual-retinoid approach is more sophisticated than most single-retinol serums at twice the price. The night serum Endocare's dermatology network prescribes for retinoid-tolerant patients who want clinical-grade results without the irritation of prescription tretinoin.
The key active ingredients in Renewal Retinol Intensive Serum are Hyaluronic Acid, Peptides, Retinol, Vitamin E (Tocopherol). It's known for: dual retinoid: retinol + HPR — immediate + sustained retinoid activity and Argireline peptide for expression-line softening alongside the retinoids.
Yes, Renewal Retinol Intensive Serum targets fine lines, dullness, hyperpigmentation. dual retinoid: retinol + HPR — immediate + sustained retinoid activity
Renewal Retinol Intensive Serum retails for around $45, which places it in the mid range for serums. Check the "Where to Buy" section above for current retailer prices.
The main drawbacks to be aware of: retinol is contraindicated in pregnancy; dual retinoid may still irritate unacclimatised skin — tolerance build-up required; HPR research is newer and smaller-scale than retinol's evidence base.
A suggested daily routine featuring this product, with complementary picks.
Ultime8 Sublime Beauty Cleansing Oil
Shu Uemura · cleanser
Gokujyun Premium Hyaluronic Acid Lotion
Hada Labo · toner
Vegan Kombucha Tea Essence
Dr. Ceuracle · essence
Renewal Retinol Intensive Serum
Endocare · serum
Cellage Firming Cream
Endocare · moisturizer
