ISDIN vs Sesderma — side by side, no bias.
Our pick
Isdinceutics Retinal Intense
9/10 · ISDIN
| Isdinceutics Retinal Intense | Daeses Liposomal Serum | |
|---|---|---|
| Brand | ISDIN | Sesderma |
| Category | serum | serum |
| Editor Rating | 9/10 ★ | 8.5/10 |
| Category | serum | serum |
| Texture | Concentrated serum | Lightweight peptide serum |
| Finish | Smooth, absorbed | Velvet |
| Skin Types |
| Targets |
| Pros |
|
|
| Cons |
|
|
| Verdict | ISDIN's retinaldehyde powerhouse — a step above retinol in the vitamin A hierarchy. Retinal (retinaldehyde) converts to retinoic acid in one step instead of two, meaning faster results with less irritation than prescription tretinoin. ISDIN pairs it with HPR (hydroxypinacolone retinoate) for a dual-retinoid approach, plus bakuchiol as a botanical synergist and hyaluronic acid for hydration. The Spanish derm brand's most serious anti-aging product. | Sesderma's Daeses uses liposomal delivery for an unusual peptide stack: Argireline + Palmitoyl Tetrapeptide-7 + Tripeptide-1, plus DMAE (dimethylethanolamine, a controversial firming ingredient), and Nicotiana Benthamiana hexapeptide-40 sh-Polypeptide-77 (a plant-bioengineered peptide — Spanish biotech). €65 for a four-peptide liposomal serum. |
