MartiDerm vs Sesderma — side by side, no bias.
Our pick
Photo-Age HA+ Ampoules
9.1/10 · MartiDerm
| Photo-Age HA+ Ampoules | Reti Age Anti-aging Serum | |
|---|---|---|
| Brand | MartiDerm | Sesderma |
| Category | serum | serum |
| Editor Rating | 9.1/10 ★ | 8.5/10 |
| Category | serum | serum |
| Texture | Watery serum in single-dose glass ampoule | Lightweight dropper serum |
| Finish | Brightened, plumped, immediately smoothed | Smooth, refined, renewed |
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| Verdict | MartiDerm's most iconic ampoule — and the Spanish 'before-the-event' beauty ritual in glass-vial form. Each 2ml nitrogen-flushed ampoule carries 5% pure L-ascorbic acid + dual-weight hyaluronic acid (sodium hyaluronate + hydrolyzed) + ferulic acid + proteoglycans (sodium chondroitin sulfate, sodium DNA — MartiDerm's house actives) + Argireline peptide. The nitrogen-flushed glass keeps the vitamin C stable at full clinical potency until the moment you snap the ampoule. The ritual of snapping a glass vial, dispensing the entire 2ml dose, applying directly to clean skin, is part of why MartiDerm is the brand Spanish women reach for the night before a wedding, a job interview, or a photographed event. At $55 for 30 ampoules (~$1.80 each), mid-tier per dose — but a fresh, oxidation-free 5% L-AA hit that bottle-format serums genuinely cannot match. | Sesderma's retinol serum — and the reason Spanish dermatologists keep recommending this brand for patients who want prescription-adjacent results without the prescription. The formulation delivers retinol through Sesderma's proprietary liposomal technology (nanosome encapsulation), which the brand has been refining for two decades. The liposomal delivery system serves two purposes: it stabilizes the retinol against oxidation (extending shelf life and potency) and it enhances penetration depth (delivering retinol below the stratum corneum where it can influence fibroblast activity). Hyaluronic acid provides hydration support to offset retinol's drying tendency. At ~$48 for 30ml, it competes directly with SkinCeuticals Retinol 0.3 and Medik8 Crystal Retinal — at roughly half the price. The liposomal encapsulation also means reduced surface irritation compared to free-form retinol at equivalent concentrations. PM use only; sunscreen the next morning is mandatory. |
