Comparison
Acniover Active Cream vs Cosmelan 2 Maintenance Cream
MartiDerm vs Mesoestetic — side by side, no bias.
MartiDerm
Acniover Active Cream
8.6/10moisturizer
Mesoestetic
Cosmelan 2 Maintenance Cream
9/10moisturizer
Our pick
Cosmelan 2 Maintenance Cream
9/10 · Mesoestetic
| Acniover Active Cream | Cosmelan 2 Maintenance Cream | |
|---|---|---|
| Brand | MartiDerm | Mesoestetic |
| Category | moisturizer | moisturizer |
| Editor Rating | 8.6/10 | 9/10 ★ |
| Category | moisturizer | moisturizer |
| Texture | Lightweight active cream | Rich treatment cream |
| Finish | Mattifying | Smoothed, brightened, restored |
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| Targets | ||
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| Verdict | Martiderm's Acniover line is the brand's acne-grade workhorse — and the Active Cream is what dermatologists pair with the Acniover serum or post-treatment. Niacinamide leads, then potassium azeloyl diglycinate (a more soluble, non-irritating azelaic acid derivative), salicylic acid, and zinc PCA. Three-front sebum/acne attack with bisabolol + allantoin for buffering. €29 for clinical-grade acne work. | Mesoestetic's at-home counterpart to the Cosmelan in-clinic depigmenting peel — and the most-prescribed melasma maintenance cream in global dermatology. The Cosmelan method is a two-step protocol: an in-clinic mask applied by an aesthetic physician, then 6-9 months of at-home Cosmelan 2 cream to maintain and extend the depigmenting effect. The maintenance cream's active stack is dense — azelaic acid, kojic acid, phytic acid, ascorbyl glucoside, retinyl palmitate, niacinamide, and arbutin all work in parallel through different melanin-synthesis pathways. The result is a cumulative, multi-month depigmenting protocol that can rival in-clinic results when used as directed. At $130 for 30g, premium pricing — but Cosmelan 2 alone (without the in-clinic peel) still delivers meaningful results for stubborn melasma that other OTC products can't move. |