activeWell-Known
Coenzyme Q10 (Ubiquinone)
Also known as: ubiquinone, coq-10, coenzyme-q10
Medically reviewed by ChokChok · Updated April 14, 2026
The antioxidant your mitochondria already make — until they stop. Topical CoQ10 tops it back up.
What It Does
antioxidantsupports mitochondrial energyreduces fine lines
Deep Dive
Coenzyme Q10 is a fat-soluble quinone present in every human cell, essential for mitochondrial ATP production. Cellular CoQ10 production declines starting in the late 20s and drops sharply after 40 — which tracks with the visible effects of aging. Topical CoQ10 penetrates the stratum corneum in small quantities, where it neutralizes lipid peroxidation in the skin barrier. Clinical data show measurable reduction in crow's feet depth at 0.3% over 6 months. Nivea's Q10 line is the category-defining mass product; Eucerin, Dr. Grandel and Susanne Kaufmann sell clinical-grade versions. An underrated workhorse.
Best For
Mature
Pairs Well With
Effective Concentration
0.05–1% in creams. Small range — higher doesn't penetrate better.