Brand Comparison
Rejuran vs Isoi
A head-to-head comparison of two popular K-beauty brands. Which one is right for your skin?
Our Pick
Rejuran
Higher editor rating (8.7 vs 8.6)
Rejuran
Rejuran is the consumer-skincare arm of Pharma Research Products, the Korean biopharma company that developed the original Rejuran Healer injectable — the same PDRN (polydeoxyribonucleotide) dermal treatment that's been a staple of Korean aesthetic clinics since 2014. The topical line translates that clinical DNA into daily-use products, anchored by the patented c-PDRN® complex at 0.5% concentration plus proprietary DOT® (Dermal Optimizing Technology) delivery. The Turnover Ampoule is the hero: a lightweight serum that targets fine lines, firmness, and texture with the same salmon-DNA active that made the injectable famous. Rejuran launched at Sephora US in 2024, won the 2025 Olive Young Slow Aging award, and has become the face of the PDRN trend that's dominating K-beauty in 2025–2026. The price point is premium-mid ($45–55), justified by the clinical pedigree and patented delivery system. Worth reaching for if you want the PDRN trend from the company that actually invented it.
Pros
- ✓ invented the PDRN category — the original, not a copycat
- ✓ patented c-PDRN® and DOT® delivery backed by published clinical data
- ✓ available at Sephora US, Olive Young Global, Amazon
- ✓ fragrance-free, cruelty-free, paraben-free across the line
Cons
- ✗ premium-mid pricing ($45–55) in a space filling with budget PDRN alternatives
- ✗ small SKU count — focused but limited range
- ✗ the salmon-DNA story can feel gimmicky until you read the papers
- ✗ injectable brand heritage may confuse consumers expecting instant clinical results from topicals
Isoi
Isoi has been quietly excellent for nearly two decades, but 2025 is its breakout year. The Blemish Care Up Serum picked up multiple Hwahae nods, and dermatology-leaning K-beauty fans have been quietly recommending it for fading post-acne marks for years. Premium-leaning but worth it.
