In Clinicinjectable
Salmon DNA Polynucleotide Injectable
Medically reviewed by ChokChok · Updated April 29, 2026
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Salmon DNA injectable — marketed under brand names including Rejuran, Plinest, and Newest — is a polynucleotide-based skin booster derived from purified salmon DNA. The treatment delivers regenerative biostimulation through micro-injection, stimulating fibroblast activity and tissue repair. Popular across Korean and Italian aesthetic medicine for skin quality, fine line reduction, and post-procedure recovery.
How It Works
Topical numbing cream applied 20-30 minutes before treatment. Polynucleotide solution (typically 1-2ml) injected via fine needle in micro-aliquot doses across dermis at multiple points across treatment area. Polynucleotides bind to fibroblast receptors over weeks, stimulating collagen synthesis, HA production, and tissue repair. Multiple sessions deliver compounding regenerative effect.
What to Expect
20-30 minute injection session in clinic. Multiple small needle pricks across treatment area. Immediate post-treatment: small wheals visible for 1-2 hours, mild redness and swelling for 24-48 hours. Mild bruising possible at injection sites. Effects develop gradually over 4-8 weeks.
Deep Dive
Polynucleotides — short fragments of DNA — have been used in regenerative medicine for decades, with strong applications in wound healing, retinal damage repair, and tissue regeneration. The cosmetic application uses purified polynucleotides extracted from salmon DNA (chosen for high purity and low immunogenicity profile) injected micro-aliquot doses across the dermis.
The mechanism is genuinely regenerative rather than volumizing or paralyzing. Polynucleotides bind to fibroblast adenosine receptors (A2A pathway) and signal increased collagen synthesis, hyaluronic acid production, and tissue repair processes. Unlike hyaluronic acid fillers (which add volume immediately) or neuromodulators (which paralyze muscle), polynucleotide skin boosters produce gradual quality improvements — better skin texture, denser dermis, finer lines, faster wound recovery.
The treatment is most-popular in Korea (Rejuran is the dominant Korean brand) and Italy (Plinest is the Italian brand). Adoption in other markets is growing as the regenerative-medicine positioning resonates with clients who want skin-quality improvement rather than aesthetic transformation.
Different from PRP (platelet-rich plasma — uses patient's own blood) and exosome therapy (uses mesenchymal stem cell secretions). Polynucleotide treatment uses standardized purified pharmaceutical-grade product, providing more consistent results than the variable autologous PRP approach.
Pros
- ✓ Genuinely regenerative mechanism vs. volumizing or paralyzing
- ✓ Standardized pharmaceutical-grade product
- ✓ Pairs with most other aesthetic treatments
- ✓ Strong Korean and Italian clinical track record
Cons
- ✗ Multiple sessions required for visible result
- ✗ Premium pricing for series
- ✗ Salmon allergen concerns for some clients
- ✗ Fewer long-term safety studies than HA fillers
Risks & Side Effects
- ⚠ Bruising at injection sites
- ⚠ Allergic reaction (especially in seafood-allergic clients)
- ⚠ Rare: infection at injection sites with improper technique
✗
Pregnancy Safety
Avoid during pregnancy
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This is not medical advice. Always consult your healthcare provider or dermatologist before trying new treatments, especially in-clinic procedures.
Routines for Related Concerns
Step-by-step K-beauty routines that complement Salmon DNA Polynucleotide Injectable.
Frequently Asked Questions
How often should I do Salmon DNA Polynucleotide Injectable?
Series of 3-4 sessions, 2-4 weeks apart; maintenance every 6-12 months. Most people see results within initial improvement at 2-4 weeks; full regenerative effect at 8-12 weeks of consistent series.
Does Salmon DNA Polynucleotide Injectable hurt?
The pain level for Salmon DNA Polynucleotide Injectable is moderate. Downtime: 24-48 hours of mild swelling and possible bruising.
Is Salmon DNA Polynucleotide Injectable safe during pregnancy?
Salmon DNA Polynucleotide Injectable should be avoided during pregnancy. Consult your healthcare provider about safer alternatives.
What are the risks of Salmon DNA Polynucleotide Injectable?
The main risks and side effects to be aware of: Bruising at injection sites; Allergic reaction (especially in seafood-allergic clients); Rare: infection at injection sites with improper technique. Always consult a qualified provider, especially for in-clinic procedures.
How much does Salmon DNA Polynucleotide Injectable cost?
Salmon DNA Polynucleotide Injectable is in the premium range. Typical cost: $300-700 per session in US/EU; $200-500 in Korea and select Asian markets.