In Clinicinjectable
Profhilo
Medically reviewed by ChokChok · Updated April 23, 2026
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Bio-remodeling injectable hyaluronic acid that spreads under the skin to stimulate collagen and elastin — not a filler, not a volumiser, a quality-of-skin booster.
How It Works
A highly concentrated, non-cross-linked hyaluronic acid is injected at five fixed subcutaneous points per side of the face ('BAP technique'). Because the HA isn't chemically cross-linked, it spreads through the dermal tissue over the following hours, where it hydrates at depth and triggers fibroblast activity. Over 4–8 weeks, collagen I, collagen III, and elastin synthesis increase measurably. The result isn't volume — it's improved skin firmness, elasticity, and texture.
What to Expect
Numbing cream applied for 20–30 minutes pre-procedure. The injections themselves take ~10 minutes total (10 points). Mild stinging at each point. Immediately after: visible small bumps at each injection site (the HA hasn't spread yet) for 4–24 hours, then they flatten. Mild bruising at injection sites possible. Day 2 onward: no visible marks. Results build from week 2, peak at week 6–8. Standard protocol: 2 treatments 4 weeks apart, then maintenance every 6–9 months.
Deep Dive
Profhilo (IBSA Derma, Switzerland) is the landmark bio-remodelling injectable — a stabilised, 100% pure hyaluronic acid at an unusually high concentration (64mg HA per 2ml syringe) that uses IBSA's proprietary NAHYCO thermal cross-linking rather than chemical cross-linkers. The result is an HA that spreads through the dermal layers after injection instead of staying localised like a filler, stimulating fibroblasts to produce new collagen and elastin over the following weeks. The technique — developed by Italian cosmetic surgeons Alessandro Gennai and Tracey Sampogna — uses five fixed injection points per side ('BAP points': Bio-Aesthetic Points) targeting the malar fat pad, pre-auricular zone, chin, and mandibular angle. Results appear progressively over 4–8 weeks and last 6–9 months before a refresh is indicated. Unlike fillers, Profhilo doesn't add volume or contour — it improves skin quality: texture, firmness, elasticity, and that poorly-defined 'glow' that sun damage and ageing strip away. Particularly popular in the GLP-1-weight-loss / 'Ozempic face' era as a skin-quality restorer when filler would look overdone.
Pros
- ✓ minimal downtime — lunch-hour procedure with no visible bruising the next day in most patients
- ✓ improves skin quality + glow without adding volume
- ✓ published clinical data on collagen + elastin stimulation
- ✓ particularly effective for GLP-1 weight-loss facial laxity
Cons
- ✗ expensive — full initial course (2 sessions) is $1,000–1,800
- ✗ results last 6–9 months, not permanent
- ✗ requires a skilled injector — wrong depth or wrong points reduces the bio-remodeling effect
- ✗ subtle results — patients expecting filler-level dramatic change will be disappointed
Risks & Side Effects
- ⚠ bruising at injection points
- ⚠ small palpable lumps for 24 hours post-injection
- ⚠ rare: Tyndall effect if injected too superficially
- ⚠ rare: vascular occlusion if a vessel is inadvertently entered
✗
Pregnancy Safety
Avoid during pregnancy
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This is not medical advice. Always consult your healthcare provider or dermatologist before trying new treatments, especially in-clinic procedures.
Routines for Related Concerns
Step-by-step K-beauty routines that complement Profhilo.
Products That Complement Profhilo
Products featuring the same key active ingredients — great for extending results between treatments.
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Frequently Asked Questions
How often should I do Profhilo?
2 initial treatments 4 weeks apart, then maintenance every 6–9 months. Most people see results within visible skin-quality improvement from week 2, peak results at week 6–8.
Does Profhilo hurt?
The pain level for Profhilo is mild. Downtime: Essentially none — small bumps at injection sites flatten in 4–24 hours, occasional mild bruising.
Is Profhilo safe during pregnancy?
Profhilo should be avoided during pregnancy. Consult your healthcare provider about safer alternatives.
What are the risks of Profhilo?
The main risks and side effects to be aware of: bruising at injection points; small palpable lumps for 24 hours post-injection; rare: Tyndall effect if injected too superficially. Always consult a qualified provider, especially for in-clinic procedures.
How much does Profhilo cost?
Profhilo is in the premium range. Typical cost: $500–900 per session (typically 2 sessions in the initial course).
