PeptideWell-Known
Matrixyl (Palmitoyl Pentapeptide-4)
Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS
Medically reviewed by ChokChok · Updated April 15, 2026
The peptide with the best clinical evidence — stimulates collagen synthesis without the irritation of retinoids.
What It Does
Anti-agingStimulates collagenReduces fine lines
Deep Dive
Matrixyl is a "signal peptide" that mimics procollagen fragments, tricking skin into producing more collagen. Multiple published studies show measurable reduction in fine-line depth over 12 weeks. Not as dramatic as retinoids but well-tolerated and pregnancy-safe. The Ordinary Matrixyl 10% + HA is the most accessible benchmark.
Best For
MatureDry
Pairs Well With
Effective Concentration
3–10%. Often combined with Matrixyl 3000 or other peptide complexes.
