What does Bifida Ferment Lysate do for skin?

Bifida Ferment Lysate is a fermented used in K-beauty for Barrier repair, Anti-inflammatory, Protects skin DNA from UV damage. The "repairs skin while you sleep" ingredient that made Advanced Night Repair the best-selling prestige serum worldwide for 30 years.

Is Bifida Ferment Lysate safe during pregnancy?

There is limited safety data on Bifida Ferment Lysate during pregnancy. Exercise caution and consult your healthcare provider before use.

What skin types is Bifida Ferment Lysate best for?

Bifida Ferment Lysate is particularly well-suited to mature, sensitive, normal skin.

What ingredients pair well with Bifida Ferment Lysate?

Bifida Ferment Lysate layers well with niacinamide, hyaluronic acid. These combinations are common in K-beauty routines and have no known negative interactions.

How strong is the evidence for Bifida Ferment Lysate?

We rate the clinical evidence for Bifida Ferment Lysate at 3/5 — moderate. The hero ingredient of Estée Lauder Advanced Night Repair. Used at 5–50%.

fermentedWell-Known

Bifida Ferment Lysate

Also known as: Probiotic ferment

3/5— Moderate Evidence

Medically reviewed by ChokChok · Updated April 15, 2026

The "repairs skin while you sleep" ingredient that made Advanced Night Repair the best-selling prestige serum worldwide for 30 years.

What It Does

Barrier repairAnti-inflammatoryProtects skin DNA from UV damage

Deep Dive

Lysate derived from Bifidobacterium species, typically grown on milk substrate. Research suggests topical application enhances barrier function and accelerates recovery from UV damage. The marquee ingredient of Estée Lauder's Advanced Night Repair (ANR) serum since the 1980s. Genuinely evidence-backed, though ANR's branding outpaces the ingredient's literal effect.