Polynucleotide (PN) Skin Booster

Numbing cream applied for 20–30 minutes. PN solution (typically 2ml of 2% concentration) injected via fine needle in a fan or grid pattern across the treatment area. The polynucleotides act as scaffolding for new tissue formation and signal fibroblasts to upregulate collagen + elastin synthesis over the following 4–8 weeks. Standard protocol: 3 initial sessions 2–4 weeks apart, then maintenance every 6–9 months.

Numbing cream for 20–30 minutes. Mild stinging during injection. Visible small bumps at injection points for 4–24 hours, then they flatten. Mild bruising possible. Day 2 onward: no visible marks. Results build progressively from week 2, peak at week 6–8 after the 3rd session.

Polynucleotides (PN) are highly purified DNA fragments derived from salmon trout sperm — the same ingredient family as PDRN (Polydeoxyribonucleotide), but with longer chain lengths and a different proposed mechanism of action. While PDRN works primarily through the A2A adenosine receptor pathway (anti-inflammatory + pro-angiogenic), PN polynucleotides act as a fibroblast scaffold and tissue-regeneration signal, with stronger published data on collagen stimulation and skin-quality improvement. The leading brands in clinic use are Plinest (IBSA, Italy) and Mastelli (Italy), with Korean equivalents emerging through 2024–2025. Treatment protocol: 3 sessions, 2–4 weeks apart, then maintenance every 6–9 months. Particularly popular for under-eye revitalization (where PN can be used safely), neck/décolletage skin quality, and post-acne scar improvement. The European clinical evidence is strong; FDA approval pathway is still emerging in the US. Distinct from PDRN injections (Rejuran), which use a similar but molecularly distinct ingredient at a different scale.